MovDisordV3, France, Analysis, bibRecord, 000569

Efaroxan, an alpha‐2 antagonist, in the treatment of progressive supranuclear palsy

Identifieur interne : 000569 ( France/Analysis ); précédent : 000568; suivant : 000570

Efaroxan, an alpha‐2 antagonist, in the treatment of progressive supranuclear palsy

Auteurs : Rascol [France] ; Kasia Sieradzan [Royaume-Uni] ; Hélène Peyro-Saint-Paul [France] ; Claire Thalamas [France] ; Christine Brefel-Courbon [France] ; Jean Michel Senard [France] ; Philippe Ladure [France] ; Jean Louis Montastruc [France] ; Andrew Lees (neurologue) [Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 1998-07.

RBID : ISTEX:15F0DC720320C512DF4B0A780CCBB502A45139EE

English descriptors

KwdEn :
- Adrenergic alpha-Antagonists (adverse effects), Adrenergic alpha-Antagonists (therapeutic use), Adult, Aged, Alpha‐2 antagonist, Benzofurans (adverse effects), Benzofurans (therapeutic use), Clinical trial, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Efaroxan, Female, Humans, Imidazoles (adverse effects), Imidazoles (therapeutic use), Male, Middle Aged, Neurologic Examination (drug effects), Progressive supranuclear palsy, Prospective Studies, Supranuclear Palsy, Progressive (diagnosis), Supranuclear Palsy, Progressive (drug therapy), Supranuclear Palsy, Progressive (physiopathology), Treatment Outcome.
MESH :
- chemical , adverse effects : Adrenergic alpha-Antagonists, Benzofurans, Imidazoles.
- chemical , therapeutic use : Adrenergic alpha-Antagonists, Benzofurans, Imidazoles.
- diagnosis : Supranuclear Palsy, Progressive.
- drug effects : Neurologic Examination.
- drug therapy : Supranuclear Palsy, Progressive.
- physiopathology : Supranuclear Palsy, Progressive.
- Adult, Aged, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome.

Abstract

We have tested, in a prospective randomized, double‐blind, placebo‐controlled, crossover, 12‐week study, the effects of 2 mg efaroxan, a potent alpha‐2 antagonist, given three times per day to 14 patients with progressive supranuclear palsy. Efaroxan did not induce any significant change on any motor assessment criteria. The present data do not confirm the assumption that the blockade of alpha‐2 receptors might be a useful pharmacologic strategy to improve patients with progressive supranuclear palsy.

Url:

https://api.istex.fr/document/15F0DC720320C512DF4B0A780CCBB502A45139EE/fulltext/pdf

DOI: 10.1002/mds.870130411

Affiliations:

Links to Exploration step

ISTEX:15F0DC720320C512DF4B0A780CCBB502A45139EE

Le document en format XML

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<author><name sortKey="Rascol" sort="Rascol" uniqKey="Rascol" last="Rascol">Rascol</name>
</author>
<author><name sortKey="Sieradzan, Kasia" sort="Sieradzan, Kasia" uniqKey="Sieradzan K" first="Kasia" last="Sieradzan">Kasia Sieradzan</name>
</author>
<author><name sortKey="Peyro Aint Aul, Helene" sort="Peyro Aint Aul, Helene" uniqKey="Peyro Aint Aul H" first="Hélène" last="Peyro-Saint-Paul">Hélène Peyro-Saint-Paul</name>
</author>
<author><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
</author>
<author><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
</author>
<author><name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean Michel" last="Senard">Jean Michel Senard</name>
</author>
<author><name sortKey="Ladure, Philippe" sort="Ladure, Philippe" uniqKey="Ladure P" first="Philippe" last="Ladure">Philippe Ladure</name>
</author>
<author><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean Louis" last="Montastruc">Jean Louis Montastruc</name>
</author>
<author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name>
<affiliation><country>Royaume-Uni</country>
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<author><name sortKey="Sieradzan, Kasia" sort="Sieradzan, Kasia" uniqKey="Sieradzan K" first="Kasia" last="Sieradzan">Kasia Sieradzan</name>
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<author><name sortKey="Peyro Aint Aul, Helene" sort="Peyro Aint Aul, Helene" uniqKey="Peyro Aint Aul H" first="Hélène" last="Peyro-Saint-Paul">Hélène Peyro-Saint-Paul</name>
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<author><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name>
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<author><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean Louis" last="Montastruc">Jean Louis Montastruc</name>
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<author><name sortKey="Lees, Andrew" sort="Lees, Andrew" uniqKey="Lees A" first="Andrew" last="Lees">Andrew Lees (neurologue)</name>
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<term>Adrenergic alpha-Antagonists (therapeutic use)</term>
<term>Adult</term>
<term>Aged</term>
<term>Alpha‐2 antagonist</term>
<term>Benzofurans (adverse effects)</term>
<term>Benzofurans (therapeutic use)</term>
<term>Clinical trial</term>
<term>Cross-Over Studies</term>
<term>Dose-Response Relationship, Drug</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
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<term>Female</term>
<term>Humans</term>
<term>Imidazoles (adverse effects)</term>
<term>Imidazoles (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurologic Examination (drug effects)</term>
<term>Progressive supranuclear palsy</term>
<term>Prospective Studies</term>
<term>Supranuclear Palsy, Progressive (diagnosis)</term>
<term>Supranuclear Palsy, Progressive (drug therapy)</term>
<term>Supranuclear Palsy, Progressive (physiopathology)</term>
<term>Treatment Outcome</term>
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<term>Imidazoles</term>
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<term>Imidazoles</term>
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<front><div type="abstract" xml:lang="en">We have tested, in a prospective randomized, double‐blind, placebo‐controlled, crossover, 12‐week study, the effects of 2 mg efaroxan, a potent alpha‐2 antagonist, given three times per day to 14 patients with progressive supranuclear palsy. Efaroxan did not induce any significant change on any motor assessment criteria. The present data do not confirm the assumption that the blockade of alpha‐2 receptors might be a useful pharmacologic strategy to improve patients with progressive supranuclear palsy.</div>
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<name sortKey="Peyro Aint Aul, Helene" sort="Peyro Aint Aul, Helene" uniqKey="Peyro Aint Aul H" first="Hélène" last="Peyro-Saint-Paul">Hélène Peyro-Saint-Paul</name>
<name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean Michel" last="Senard">Jean Michel Senard</name>
<name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Sieradzan, Kasia" sort="Sieradzan, Kasia" uniqKey="Sieradzan K" first="Kasia" last="Sieradzan">Kasia Sieradzan</name>
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Movement Disorders (revue)

Efaroxan, an alpha‐2 antagonist, in the treatment of progressive supranuclear palsy

Efaroxan, an alpha‐2 antagonist, in the treatment of progressive supranuclear palsy

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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